Expression level of SNCG is positively relevant to tumor progression across various types of cancers.[47] And elevated expression of SNCG confers resistance to anti‐cancer treatment.[48] As a co‐chaperone, SNCG could interact with multiple kinases in cytotoxic situation, increasing stability of Akt and activating mitogen‐active protein kinase pathways,[49] or regulating microtubule by acting with mitotic checkpoint kinase BubR1.[50] Our results reveal the close relationship between highly expressed SNCG and budding of irradiation‐induced RTP cells. Here, SNCG is linked to neoplasm.