Recently, PACCs have been proposed as the “evil roots of cancer” with mounting evidences showing their potent ability of survival, stemness and resistance to oncotherapy.[8] PACCs have been proposed to originate from endoreplication, mitotic failure or abortive cytokinesis, especially in the cells with dysfunctional p53 (TP53)[9] and their frequency is correlated with advanced tumor staging and worse prognosis.[8, 10] Traditional molecular methods used to analyze PACCs only obtained average information, precluding the identification of those PACCs with repopulating potentials. The gene discussed is TP53; the disease is cancer.