Compound 110 decreased SLC7A11, cysteine, and GSH levels enhanced the expression of NOX4, which reduces oxygen to superoxide radical anions, rose the labile iron pool, and surprisingly upregulated GPX4 in diverse rat and human glioma cell lines (C6, SHG‐44, U87, U251) and/or grafted tumors in mice. The gene discussed is GPX4; the disease is central nervous system cancer.