The bufadienolide 108 (20–40 μM) (Figure 13) isolated from Asiatic toad (Bufo gargarizans) increased MDA, iron, and ROS levels, decreased GPX4 expression, reduced the availability of GSH and triggered ferroptosis in human HT29 and SW480 CRC cells.372. Here, GPX4 is linked to colorectal carcinoma.