Inhibition of PERK, ATF4, and HSPA5 (either using a pharmacological inhibitor or siRNA) substantially increased the sensitivity of cultured and grafted glioma cells to 102, which indicates that targeting the PERK branch of the unfolded protein response might be an effective means to increase the vulnerability of tumors against ferroptosis induction by 98 and derivatives. The gene discussed is EIF2AK3; the disease is glioma.