CD40 and neoplasm: The CD40 signaling pathway is an important trigger for numerous immunological actions, including monocyte maturation and M1 macrophages differentiation, DC activation for enhancing antigen cross‐presentation to T cells, and mediating antibody switching and somatic hypermutation in B cells.[44] A recent study reported that CD40 mAb reprograms TAM to anti‐tumor phenotype and accumulates tumor‐infiltrated immune cells along with TCR‐engineered T cells.[45] Therefore, tuning the application of CD40 mAb to obtain the optimal treatment efficacy is crucial.