‐Lyve‐1+ CD163+ Tim4+ tissue‐resident omental macrophages that expressed genes associated with positive regulation of JAK‐STAT signaling, linked with macrophage self‐renewal and genes associated with tumor‐promoting functions.‐Lyve‐1+ CD163+ Tim4‐ monocyte‐derived omental macrophages expressed genes associated with tumor‐promoting functions. The gene discussed is SOAT1; the disease is neoplasm.