Given that PDZD8 is a risk factor for syndromic ID with autistic features [25] and for PTSD [32] in humans, we performed a battery of behavioral tests to examine the possible effects of PDZD8 ablation on physiological endophenotypes with the use of 18 wild-type (WT) and 19 PDZD8-KO male mice on the C57BL/6 J background that were obtained as a single cohort by heterozygote intercrossing. Here, PDZD8 is linked to post-traumatic stress disorder.