In contrast, PDZD8-KO mice (exon 1-deleted) showed novel phenotypes such as increased sensorimotor gating and reduced cued fear conditioned memory and working memory, as well as the similar abnormalities to Pdzd8tm1b mice such as restricted growth, hyperactivity, and decreased anxiety and fear (Additional file 2: Table S1). Here, PDZD8 is linked to Anxiety.