AKT1 and cancer: A growing body of evidence has demonstrated that the expression level of MMP 2 and MMP 9 in several cancer types is regulated by multiple signaling pathways, includ-ing the wnt/β catenin pathway, and the hedgehog signaling pathway, the phosphoinositide-3 ki-nase (PI3K)/AKT pathway, and the mitogen-activated protein kinase (MAPK) pathway [40–42].