Lastly, while p-NfM/H and NfL co-localized in most of the control axons, axons in the deep cortical layers of PD and PDD/DLB cases were mostly positive for p-NfM/H or NfL, rarely showing co-localization of the two neurofilaments (Fig. 3f–h). Here, NEFM is linked to Parkinson disease.