Overall, p-NfM/H immunoreactivity was significantly increased in both PD (P < 0.001) and PDD/DLB (P < 0.001) compared to controls by 40% and 32% respectively, and did not differ between PD and PDD/DLB (P = 1.000) (Fig. 2a, and Additional file 2: Fig. S3a for representative images). This evidence concerns the gene NEFM and Lewy body dementia.