More specifically, compared with the lowest tertile of EV-GDF15, the risk of T2DM increased by 206% in the middle tertile (OR = 3.06; 95% CI 1.02–9.19), and increased by 275% in the upper tertile (OR = 3.75; 95% CI 1.14 to 12.26) (Table 3). This evidence concerns the gene GDF15 and type 2 diabetes mellitus.