IRS1 and diabetes mellitus: The exploration of the clinical significance of EVs contents in relation to diabetes and its complications is still in its infancy, although a number of basic research has addressed the involvement of EVs contents, including miRNAs (miR-326 [13], miR-877-3p, and miR-150-5p [14]) and proteins (IRS1 [15] and ARG1 [16]) in the development of diabetes-related pathophysiological disorders.