FCGR2A and autoimmune thrombocytopenic purpura: Decreased expression of the inhibitory FcγR on macrophages, enhanced M1 macrophage polarization, and increased number of inflammatory CD16+ monocytes have been observed in patients with active ITP and are related to the enhanced phagocytosis of opsonized platelets and autoreactive T-cell priming [15, 27, 28].