CD86 and autoimmune thrombocytopenic purpura: Defects in DCs, such as elevated surface CD86 expression, reduced indoleamine 2,3-dioxygenase (IDO) levels, and lowered numbers of plasmacytoid DCs, result in enhanced stimulation of autoreactive T cells and impaired induction of regulatory T cells (Tregs) in ITP [21–24].