The antibacterial drugs to treat peri-implantitis commonly include 0.12–0.2% chlorhexidine digluconate (CHX) [23], 3% hydrogen peroxide (H2O2) [24], etc. CHX, both solution and gel, assists peri-implantitis treatment and reduces bacterial adhesion to tooth surfaces by the synergistic action of glycoproteins in saliva [25]. This evidence concerns the gene ART4 and Peri-Implantitis.