As of 2021, there are multiple FDA-approved second-line HCC treatments, including cabozantinib, immunotherapy-based regimens, and ramucirumab, a biweekly intravenous (IV) infusion approved in 2019 for patients with a serum alpha-fetoprotein (AFP) level > 400 ng/mL [5–8]. This evidence concerns the gene AFP and hepatocellular carcinoma.