The protein product of NFAT5 regulates synovial proliferation and angiogenesis in chronic arthritis [32]; the NOB1-encoded protein is likely to be a potential target for the treatment of osteosarcoma [33]; and the HAS3 product is related to hyaluronan metabolism in human keratinocytes and atopic dermatitis skin [34]. The gene discussed is NOB1; the disease is osteosarcoma.