DUX4 and acute lymphoblastic leukemia: More recently, genomic approaches have identified new genetic subtypes among B-other-ALL, including DUX4-rearranged (DUX4-r, mostly IGH::DUX4), ABL-class fusions, and MEF2D-rearranged (MEF2D-r), which have been associated with specific clinical characteristics and differing outcomes (Table 1) [4–10].