Moreover, while all but three microbiomes could activate the anti-inflammatory bowel disease (IBD) prodrug balsalazide through the azoreductase activity, the highest secretion flux of the active form of balsalazide (5-aminosalicylic acid) achieved by any microbiome was 339.81 mmol d−1 per person, while the average was 25.47 ± 40.84 mmol d−1 per person (Fig. 5a). The gene discussed is NQO1; the disease is inflammatory bowel disease.