For the Ki-67 index in lymph node metastases, a labeling index of ≥ 2.85% was predictive for tumor recurrences with a sensitivity of 76%, specificity of 52%, and AUC of 0.66 (CI 0.54–0.78, p = 0.01) (Fig. 2c). This evidence concerns the gene MKI67 and neoplasm.