mtDNA released into the cytoplasm instigates the activation of Toll-like receptors (TLRs) and the cGAS (cyclic GMP–AMP synthase)-STING (stimulator of interferon genes protein) signaling axis to induce the expression of various inflammatory cytokines and chemokines2,10, which contributes to the onset and development of hepatic fibrosis. Here, STING1 is linked to Hepatic fibrosis.