TFs involved in CRCs co-opted by MYCN in neuroblastoma (PHOX2B, HAND2, ISL1 and GATA3)15,16 and the PAX3–FOXO1 and PAX7–FOXO1 fusion proteins in alveolar rhabdomyosarcoma (MYOD1, MYOG, SOX8 and MYCN)17,18 constituted the strongest dependencies specific to each tumour type. The gene discussed is ISL1; the disease is alveolar rhabdomyosarcoma.