By contrast, selective TF gene dependencies in Ewing sarcoma were transcriptional repressors, including the known dependencies BCL11B and ZEB2 (refs. 36, 37), which are activated by EWS–FLI, and the previously uncharacterized dependency ETV6 (Fig. 1a and Extended Data Fig. 1a). Here, BCL11B is linked to Ewing sarcoma.