EWSR1 and Ewing sarcoma: The competition between EWS–FLI and ETV6 in Ewing sarcoma bears resemblance to a mechanism of ETS TF competition governing cell-fate decisions in developing Drosophila. Pointed, the activating orthologue of human Ets-1, competes for binding at ETS motifs within specific enhancers with Yan, the repressive orthologue of ETV6, to regulate the expression of key differentiation genes in distinct tissues77–81.