On the other hand, IFNγ sensing by CD8 T cells results in their exclusion from the tumor core, which might occur by the same mechanism, whereby CD8 T cells produce IFNγ at the margin, where they are primed by macrophages, which in turn would induce the expression of the chemokines CXCL9 and 1182, recruiting and retaining CD8 T cells that express the receptor CXCR3. The gene discussed is IFNG; the disease is neoplasm.