Interestingly, low-dose AF-induced enhancement of Bz-mediated ISR and CHAC1 upregulation observed in MDA-MB 435 S cells was not seen in MCF10A cells, suggesting that TrxR1/proteasome inhibition preferentially kills cancer cells via cancer-selective aggravation of proteotoxic stress (Fig. 7I). The gene discussed is CHAC1; the disease is cancer.