Given that mitochondrial OXPHOS plays an important role in cell proliferation and metastasis of certain tumors [13], in order to understand whether increased PHB2 expression promotes CRC tumorigenesis and progression by upregulating OXPHOS level, we first performed Seahorse MitoStress analysis to evaluate the effect of PHB2 knockdown on OXPHOS level of CRC cells. This evidence concerns the gene PHB2 and colorectal carcinoma.