As shown in Fig. 4A, knockdown of PHB2 altered the response of CRC cells to mitochondrial electron transport chain (ETC) complexes inhibitors (including Oligomycin, an ATP synthase (complex V) inhibitor; Carbonyl cyanide-4 (trifluoromethoxy) Phenylhydrazone (FCCP), a mitochondrial uncoupler; rotenone, a complex I inhibitor; and Antimycin A, a complex III inhibitor), indicating a significant decrease of OXPHOS level (Fig. 4A). Here, PHB2 is linked to colorectal carcinoma.