Differentially methylated regions (DMRs; see “Methods”) between RS and DLBCL were strongly enriched in targets of polycomb complex components SUZ12 (p = 1.2e−121) and EZH2 (p = 1.5e−30), which likely corresponds to the derivation of DLBCL from GC or post-GC B cells. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.