Most of the clonally expanded cells were in the same population of blood and synovial tissues and these clonally expanded populations of blood and synovial CD8+ T cells expressed high levels of GZMB and GNLY, defining the expanded citrullinated antigen-reactive cytotoxic CD8+ lineages in RA blood (Supplementary Fig. 12c). The gene discussed is GZMB; the disease is rheumatoid arthritis.