Toward this, we have utilized three mesothelioma mouse model derived cell lines, referred to as NC (Nf2−/−, Cdkn2ab−/−), BNC (Bap1−/−, Nf2−/−, Cdkn2ab−/−), and BNCP (Bap1−/−, Nf2−/−, Cdkn2ab−/−, Tp53−/−), which allow us to discover Bap1-loss-associated dependencies in a defined genetic background.15 The gene discussed is BAP1; the disease is mesothelioma.