The goal of this retrospective study was to determine ACE2 and TMPRSS2 mRNA levels in multiple swine models of pressure overload-induced heart failure to evaluate the effects of chronic exercise training tolerable to a patient with heart failure, sex, and Western diet on molecular mechanisms that may underlie observed connections between cardiovascular disease and SARS-COV-2 severity. The gene discussed is TMPRSS2; the disease is heart failure.