To further measure the effect of RNF5 inhibition on PEL tumorigenesis, we subcutaneously injected stable control BCBL1 cells or BCBL1 cells with RNF5 knockdown by shRNA or RNF5 KO using CRISPR-Cas9 into NOS/SCID mice and measured xenograft tumor growth in mice derived from these PEL cells. Here, RNF5 is linked to primary effusion lymphoma.