Although control BCBL1 and BJAB cells had the similar curve of cell growth, RNF5 depletion decreased both cell growth in low serum condition, and the growth of RNF5 KD BCBL1 cells was much slower than RNF5 KD BJAB cells (Fig 8B), indicating that the expression of RNF5 plays more important roles in cell proliferation of KSHV-positive PEL cells than non-KSHV-infected lymphoma cells. This evidence concerns the gene RNF5 and lymphoma.