These results suggest that KSHV-positive PEL cells exhibit more aggressive tumorigenesis than non-KSHV-infected lymphoma cells in NOD/SCID mice and that RNF5 silence generates more significant suppression in xenograft tumor growth of KSHV-positive PEL cells than non-KSHV-infected lymphoma cells. The gene discussed is RNF5; the disease is lymphoma.