RNF5 and primary effusion lymphoma: Although RNF5 regulates several key substrates involved in innate immunity, inflammation, and autophagy, we did not observe differential gene expression involved in these processes in RNF5 wild-type vs. RNF5-depleted BCBL1 cells and xenograft tumors (S1 Table), indicating that inhibition of RNF5 in PEL tumorigenesis was not due to these targets and pathways.