The total weights of BCBL1-derived lymphoma and ascites in the abdominal cavity were greatly reduced by RNF5 depletion when all mice were sacrificed seven weeks after injection, while no ascites or invasive tumors grew in mice injected with control or RNF5 KD BJAB cells, only small tumor-like tissues were observed in the abdominal cavity and RNF5 knockdown minimally decreased their weights (Fig 8D). The gene discussed is RNF5; the disease is neoplasm.