Having determined that expression of p53QS mimicked the biliary, but not the hepatocyte defect in ΔS6 livers, we sought to determine the extent to which each aspect of liver disease depended on p53 by breeding Rps6lox/lox:Alb-Cre mice to p53-/- mice to generate mice with livers that were deficient for Rps6 and p53 (herein referred to as ΔS6:Δp53 mice). The gene discussed is TP53; the disease is liver disorder.