We therefore lowered the threshold for malignant conversion in ΔS6 livers by co-opting the Alb-Cre transgene used to delete Rps6 to also delete the tumor suppressor Pten, a mild, yet reliable oncogenic stimulus, that by itself, results in delayed-onset liver tumor development in mice by ~1 year of age [51,52]. Here, ALB is linked to neoplasm.