RPS6 and neoplasm: However, given that the same level of c-Myc that provided hepatoprotection to ΔS6 livers during the early phase of disease also accelerated tumor development in aged ΔS6:c-Myc mice, further work is needed to determine the extent to which c-Myc’s hepatoprotective or tumor-promoting activities are influenced by other factors that are impacted by Rps6 insufficiency such as mTOR activation [132] or inflammation [133].