Importantly however, the ductopenia and cholestasis in ΔS6 livers contrasts sharply with the absence of any biliary abnormalities and relatively mild hepatic dysfunction observed in mice with Alb-Cre-mediated depletion of Dkc1 which, like Rps6, also activates p53 and disrupts rRNA processing [72]. Here, DKC1 is linked to cholestasis.