Given c-Myc’s role in positively regulating ribosome biogenesis and that rp haploinsufficiency constrains Myc-dependent oncogenesis in vivo [53], we asked how increasing the level of c-Myc in the liver altered its response to Rps6-deficiency either during the early hypoplastic phase or the later tumor-prone phase. The gene discussed is BLOC1S3; the disease is neoplasm.