ALB and hepatocellular carcinoma: This approach involved breeding ΔS6 mice to Albumin-c-Myc (Alb-c-Myc) transgenic mice [61] which express a modest level of c-Myc (~8-fold above normal) in postnatal hepatocytes (S10A and S10B Fig) that is sufficient to stimulate ribosome biogenesis and promote hepatocyte hypertrophy in livers of young mice, but unable to drive fully penetrant HCC development before 1 year of age.