TP53 and liver disorder: Using a gain-of-function approach to investigate the role of p53 in ΔS6-associated liver disease, we found that hepatoblast-specific stabilization of p53QS generally mimicked the cholangiopathy in ΔS6 livers but was unable to trigger the rapid or robust hepatocyte death that drove neonatal ΔS6 livers towards near-catastrophic failure.