GFAP and encephalomalacia: Similarly, IHC against astrocyte-specific marker glial fibrillary acidic protein (GFAP, Fig 2J–2L) showed an increased number of astrocytes or astrocytosis and fibrillary processes per astrocytes or astrogliosis surrounding the region of cryptococcal-induced encephalomalacia and GXM accumulation (Fig 2K–2L).