Understanding the regulation of p97 through adaptor proteins and PTMs is especially relevant in the context of cancer and neuromuscular disorders, since aberrant function of p97 and its interacting partners have been shown to play a significant role in cancer metastasis and diseases such as amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) (26). Here, VCP is linked to amyotrophic lateral sclerosis.