MMP14 and systemic lupus erythematosus: Conversely, SEED functions including systemic lupus erythematosus, MT1-MMP pericellular network, proteolysis pathways, oxidative stress, ECM-receptor interaction and membrane transport had significant negative correlations (Spearman correlation; r ≥ 0.5, p < 0.05) with most of the top abundant fungal species in all three metagenomes (Fig 8B).