With a goal of defining targets for therapeutic intervention, defining cell signalling pathways involved in environmental responses offers clear opportunities, but it should be noted that the TFs themselves are no longer considered “undruggable” [169–171] and that, in the case of NAFLD and NASH, there are some nuclear receptor TFs that have been targeted for therapy (Peroxisome proliferator-activated receptor (PPAR) proteins and the Farnesoid X receptor (FXR) [172]). Here, NR1H4 is linked to metabolic dysfunction-associated steatotic liver disease.