For these autologous allografts, we took advantage of a C57BL/6 primary cell line that we derived from a tumour established by a hydrodynamic gene transfer of constitutively active Ras and a simultaneous CrispR/Cas9-mediated inactivation of the p53 tumour suppressor (Bacevic et al., 2019). This evidence concerns the gene TP53 and neoplasm.