CSN3 and cancer: To do so, we looked for genes whose expression is specifically induced by high-intensity Ras signalling, both in the parental BMEL-RasHIGH cells and in the liver, as compared, respectively, to the RasLOW cells and the peritoneal tumours (Figure 5A).Out of four genes (Ceacam1, Csn3, Selp, Tmem252) that corresponded to this criterion, we focused our attention on CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), a gene widely expressed in many cancer types and whose expression level has been reported to correlate with tumour progression (Dankner et al., 2017).