Most of the identified DEGs, including PAX5, OPRD1, PCOLCE2, CDKN1C, GABRA2, IL6, PDE7B, SIRT1, SOCS1, SYT1, SYT12, SYT14, and TET1, represent findings not observed in previous transcriptomic analyses of T2D islets (1–8). Here, TET1 is linked to type 2 diabetes mellitus.