In addition to Pax5 itself, 3 of the other DEGs selected for functional follow-up, Faim2, Pcolce2, and Slc2a2, were altered in Pax5-overexpressing INS1 β cells, and in the same direction as in islets from individuals with T2D (Figure 6E). Here, PCOLCE2 is linked to type 2 diabetes mellitus.