PAX5 and type 2 diabetes mellitus: This was supported by our analysis of Pax5-overexpressing INS1 β cells, which exhibited vast transcriptomic changes, including for genes selected for functional follow-up (Faim2, Pcolce2, and Slc2a2) and for many other T2D DEGs, altered in the same direction in this model as in islets from individuals with T2D.