INS and Other metabolic disease: We then assessed whether SNPs that map to any of the 395 DEGs have been associated with T2D and/or glycemic traits (HbA1c, fasting glucose, fasting insulin, homeostatic model assessment of β cell function [HOMA-B], disposition index [DI], or corrected insulin response [CIR]) in GWAS using the Common Metabolic Diseases Knowledge Portal (hugeamp.org, accessed August 2022).