This was supported by our analysis of Pax5-overexpressing INS1 β cells, which exhibited vast transcriptomic changes, including for genes selected for functional follow-up (Faim2, Pcolce2, and Slc2a2) and for many other T2D DEGs, altered in the same direction in this model as in islets from individuals with T2D. This evidence concerns the gene FAIM2 and type 2 diabetes mellitus.