Most of the identified DEGs, including PAX5, OPRD1, PCOLCE2, CDKN1C, GABRA2, IL6, PDE7B, SIRT1, SOCS1, SYT1, SYT12, SYT14, and TET1, represent findings not observed in previous transcriptomic analyses of T2D islets (1–8). The gene discussed is OPRD1; the disease is type 2 diabetes mellitus.