Our in vitro work in beating hiPSC-CMs expands on the role of LINC00881 in human HF and suggests that it is an essential regulator of cardiomyocyte calcium cycling and an upstream transcriptional regulator of several key calcium channel and sarcomere organization genes, including CACNA1C, RYR2, and MYH6. The gene discussed is MYH6; the disease is hydrops fetalis.