NLRP3 and colitis: Next, we investigated the effects of the small-molecule inhibitors targeting NLRP3 (MCC950) and Caspase-8 (Z-IETD-FMK) on bacterial composition in fecal samples collected on day 0 and 12 from IL10−/− mice with colitis induced by AIEC/piroxicam (Figure 2a).