NLRP3 and inflammatory bowel disease: This is an SCFA producing bacteria, which can regulate Treg cells, and whose abundance is generally decreased in IBD.46,47 A similar subtle effect on microbiota composition was reported in a model of experimental autoimmune encephalomyelitis (EAE) after NLRP3-inhibitor (MCC950) administration.48 Although no increase in butyrate was noted in either of the inhibitor treatment groups, a higher induction of propionate and total SCFA was observed, potentially indicating the contribution of this genus to SCFA generation and reduced inflammation.