This is an SCFA producing bacteria, which can regulate Treg cells, and whose abundance is generally decreased in IBD.46,47 A similar subtle effect on microbiota composition was reported in a model of experimental autoimmune encephalomyelitis (EAE) after NLRP3-inhibitor (MCC950) administration.48 Although no increase in butyrate was noted in either of the inhibitor treatment groups, a higher induction of propionate and total SCFA was observed, potentially indicating the contribution of this genus to SCFA generation and reduced inflammation. This evidence concerns the gene NLRP3 and experimental autoimmune encephalomyelitis.