For PPGL, high expression of TOP2A mRNA was associated with the aPGL tumor type (as opposed to PCC), male sex (as opposed to female sex), metastasis or local recurrence (as opposed to no metastasis or local recurrence), Cluster 1 genotype (as opposed to Cluster 2 tumors), and high levels of noradrenaline (as opposed to normal levels). This evidence concerns the gene TOP2A and neoplasm.