CDK5 and Alzheimer disease: Utilizing commercially available software programs TargetScan, we found miR-650, which was significantly increased in AD samples, was predicted to bind the 3′ untranslated regions (3′-UTR) of Apolipoprotein E (APOE), Presenilin 1 (PSEN1), and Cyclin-Dependent Kinase 5 (CDK5) (Supplemental Fig. 2).