Elevated very-low-density lipoprotein receptor (VLDLR) expression in adipose tissue and macrophages promotes adipose tissue inflammation and glucose intolerance in obese mice, and we found that the VLDLR mRNA expression level decreased in the ADRQβ-004 vaccine group (ADRQβ-004: 1.4 ± 0.3 versus HFD + L-NAME: 1.8 ± 0.2, P = 0.045) (Fig. 4h). This evidence concerns the gene VLDLR and Glucose intolerance.