CD274 and neoplasm: The reduction in MDSC recruitment resulted in a decreased inhibitory effect on T cells and downregulated immune checkpoint programmed death ligand 1 PD-L1 expression [32] which could reverse MDSC-mediated immunosuppression to enhance therapeutic outcomes of immunotherapy treatment and inhibit MDSC involvement in the formation of premetastatic niches, tumour angiogenesis and tumour cell invasion [98].