Our data provide evidence for the hypothesis that, even under suppressive conditions, activated NK cells can contribute to the overall anti-tumor immunity, on the one hand by direct cytotoxicity against tumor cells and on the other hand through production of IFN-γ which can enhance antigen presentation through HLA class I upregulation and stimulate Th1 and CD8+ T cell responses [21, 30]. Here, CD8A is linked to neoplasm.