The aim of this study was to evaluate the possible relationship between changes in hemangioma-linked genes encoding for anthrax toxin receptor 1 (ANTXR1), R kinase insert domain receptor (KDR), adrenoceptor beta 2 (ADRB) and insulin-like growth factor 1 receptor (IGF-1R) and the occurrence of IVH in a population of preterm infants. The gene discussed is IGF1R; the disease is hemangioma.