CD274 and colon carcinoma: As MC-38 mouse colon carcinoma tumors are known to be sensitive to PD-1/L1 blockade therapy in preclinical models that use anti-mouse PD-1/L1 Ab clones (15, 25), we next confirmed that MC-38 tumors in HuPD-H1 mice remained sensitive to anti-mouse PD-L1 Ab (clone 10B5) (Supplemental Fig. 2F, 2G).