This can be explored in future experiments However, the current study would suggest that the quality of Ag-specific T cells rather than the quantity of Ag-specific T cells plays a critical role in response to ICI therapy, as all mice in our study, including controls, had a robust tumor-specific T cell immune response to the OVA Ag, but only in mice treated with an ICI at the time of priming showed effective antitumor immunity. The gene discussed is RENBP; the disease is neoplasm.