GLI1 and craniosynostosis: Ablation of GLI1 +SuSCs leads to craniosynostosis, a premature closure of cranial sutures resulting in arrested skull growth (Zhao et al., 2015; Durham et al., 2019), while impaired cell proliferation and osteogenic differentiation of SuSCs is associated with wide-open fontanels due to reduced or delayed bone growth (Goto et al., 2004; Qin et al., 2019).