Pathway and ontology analysis of the shared FEM hubs with seed genes cdk6 and tfdp2 (Figure 5B) highlighted G1 to S cell cycle control (WP45), cell cycle (WP179), and G1/S phase transition, SCF/SKP2 complex, TP53 signalling, and DREAM complex cell cycle progression in cancer. The gene discussed is SKP2; the disease is cancer.