Strikingly, there was a moderate negative correlation (ρ between −0.5 to −0.6; q value of <0.05) between interferon signaling (OAS2, OAS3, IFIT1, UPS18, ISG20, IFITM1, ISG15, and OASL), chemokine receptor signaling (CXCL 10 and CXCL11), and adaptive immune system (IFITM1, CD300E, and SIGLEC1) genes with SARS-CoV-2 CT values in symptomatic, mild-to-moderate COVID-19 adults (Fig. 3). The gene discussed is ISG15; the disease is COVID-19.