APOE and liver disorder: The composition of a PC strongly depends on the shape, size, and molecular composition of the NP.19 For instance, large hydrophobic particles will form distinct PCs compared to small positively charged NPs.20 The PC can drastically affect the stability and biodistribution of the drug delivery vehicle.19,21 For example, NPs that bind to apolipoprotein E (APOE) are often trafficked to the liver, which can be exploited for therapeutics designed for hepatic diseases.22 However, for drugs that need to be delivered elsewhere, APOE binding can lead to liver toxicity.