The extracellular matrix (ECM) is a cell-secreted dynamic fibrillar network that controls cellular activities under physiological conditions such as embryonic development and wound repair, and disease conditions, such as cancer progression or fibrosis-related diseases.222–225 The ECM contains various matrix proteins, especially fibrillar proteins such as FN and collagen, that have specific domains allowing them to interact with one another as well as cell receptors. Here, FN1 is linked to cancer.