Importantly, 4 variants (rs2522833/PCLO, rs2715147/PCLO, rs9416742/ BICC1, and rs999845/ BICC1) in MDD and 1 (rs6127921/BMP7) variant with antidepressant response are of high potential as they are significantly associated in both candidate and GWAS studies. The gene discussed is BMP7; the disease is major depressive disorder.