The periodontitis-induced maladaptive training of myelopoiesis was crucially dependent on IL-1 signalling in HSPCs; indeed, training failed in mice with HSPC-specific deletion of IL-1 receptor.76 This finding suggests that systemic inhibition of IL-1 or the IL-1 receptor could suppress the maladaptive training of HSPCs and thereby block a central causal mechanism for inflammation chronicity and inflammatory comorbidities. This evidence concerns the gene IL1B and periodontitis.