In the present study, we observed increased levels of IL-8, IL-6, TNF-α, IFN-γ and IL-1β in the skin of monobenzone-induced vitiligo mice, and LBP significantly inhibited secretion of IL-8, IL-6, TNF-α, IFN-γ and IL-1β. The gene discussed is IFNG; the disease is vitiligo.