Monobenzone is a skin depigmenting agent that acts on melanocyte tyrosinase, induces pigment loss, forms quinone haptens, induces vitiligo-like immune responses through cross-presentation of immature human dendritic cells and autologous T lymphocytes and causes depigmentation in hyperpigmented skin and non-directly exposed areas (Arowojolu et al. Here, TYR is linked to vitiligo.