2,3,5,4′‐Tetrahydroxystilbene‐2‐O‐glucoside enhanced the cardioprotective impact of temporary hypoxia on hypoxia/reoxygenation (H/R) by inhibiting excessive reactive oxygen species (ROS) generation and calcium overload via increased mitochondrial energy metabolism (Cheng et al., 2018), and significantly prevented the development of atherosclerotic (AS) plaques in apolipoprotein E (ApoE)−/− mice and decreased atherosclerosis (AS) through control of the total gut microbiota composition (Li et al., 2020). Here, APOE is linked to atherosclerosis.