It is proposed that IL‐10 is an anti‐inflammatory, immunomodulatory cytokine that is shown to improve neurological injuries like ST (Huang, 2020) and depression (Audet & Anisman, 2013) and acts against excitotoxicity through the inhibition of TNF‐α synthesis (Bethea et al., 1999). This evidence concerns the gene TNF and major depressive disorder.